COVID-19 Testing Solution

Antibody Testing Based On An Innovative Technology

The Solution

Working jointly with our partner Albany Medical College, FluroTest seeks to advance the Platform Technology developed by FluroTech to rapidly detect the presence and viral load (quantity of viral particles per ml), with the 2019 novel coronavirus SARS-CoV-2 (or “COVID-19”) as the initial target virus.

The detection of the of the virus will be mediated by specific antibodies targeting Covid-19. Additionally, the use of harmless virus particles/components (ex. capsid, spike proteins, among others) could allow for the detection of anti-SARS-CoV-2 human antibodies in a patient’s blood sample, potentially confirming the development of immunity. The goal is to utilize specific fluorescence-labeled antibodies with the ability to target a specific virus and/or labeled virus components.

The Product

FluroTest’s technology development efforts require unique expertise in spectroscopy and fluorescence as well as immunology and virology. This initiative is a collaborative effort between U.S. and Canadian scientists with deep experience in their respective fields.

For immunology and virology expertise, FluroTest has partnered with Albany Medical College’s (AMC) immunology and microbial disease department. AMC is located in the State of New York. The Department’s research team is led by Dr. Dennis Metzger, professor and chair of the department. Dr. Metzger’s research program concentrates on mucosal immune responses and the mechanisms responsible for viral-bacterial synergy in the lung. AMC is in a unique position to begin large scale sample collection and clinical trials which will assist in obtaining regulatory approvals including the FDA.

For fluorescence spectroscopy expertise, the Company is relying on FluroTech’s laboratory at the University of Calgary, led by Dr. Elmar Prenner. Dr. Prenner is the original developer of the technology owned by AB Photonics. Dr. Prenner, a professor at the University of Calgary within the department of Biological Sciences, serves as senior science advisor of FluroTech and brings over 28 years of expertise in fluorescence spectroscopy.

The Science

When a small fluorescence molecule is irradiated with a polarized light its light emission will be depolarized, due to its size and innate fast motion or rotation when in solution. In contrast, a larger fluorescent molecule, with a slower motion/rotation ability, will maintain a similar level of light polarization during its emission. In the case of antibodies and virus detection, the antibodies can be labelled with a fluorescent dye. Under this condition the dye will emit certain degree of depolarized light. However, if the labelled antibody binds a large molecule, such as Covid-19, the size of the dye-containing complex will largely increase, and the emitted light will preserve most of the original polarization.